Microfluidic-Enabled Liposomes Elucidate Size-Dependent Transdermal Transport
نویسندگان
چکیده
Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport of nanoscale lipid vesicles. While large liposomes with diameters above 105 nm are found to be excluded from deeper skin layers past the stratum corneum, the primary barrier to nanoparticle transport, liposomes with mean diameters between 31-41 nm exhibit significantly enhanced penetration. Furthermore, multicolor fluorescence imaging reveals that the smaller liposomes pass rapidly through the stratum corneum without vesicle rupture. These findings reveal that nanoscale liposomes with well-controlled size and minimal size variance are excellent vehicles for transdermal delivery of functional nanoparticle drugs.
منابع مشابه
The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin.
To overcome the problems associated with conventional liposomes in transdermal drug delivery like limited penetration ability and poor stability, in this article we report a new generation of cell penetrating peptide polyarginine containing nano-liposomes conjugated with carbon dots. The newly synthesized, cost-effective liposomic precursors were used for the fabrication of liposomes. The resul...
متن کاملLamivudine Liposomes for Transdermal Delivery - Formulation, Characterization, Stability and In vitro Evaluation
Lamivudine, an antiretroviral is commonly used in the treatment of HIV infections. Upon oral administration, it exhibits dose dependent toxic effects such as hepatotoxicity, hyperglycemia, hyperlipidemia, lactic acidosis, lipodystropy, osteonecrosis. These side effects often require dosage reduction or even cessation of treatment. Thus, the problems associated with oral administration led us to...
متن کاملUltrasound-enhanced microfluidic synthesis of liposomes.
BACKGROUND Liposomes have been successfully used as delivery vehicles for anticancer drugs. Both sonication and microfluidic technologies have been used to produce liposomes. The combination of the two methods was evaluated in this study. MATERIALS AND METHODS The microfluidic devices, mainly comprising micro-dispensers and a sonicator, were used to produce liposomal nanoparticles. Sonication...
متن کاملPharmacy-on-a-chip: Microfluidic Synthesis of Pegylated and Folate Receptor-targeted Liposomes for Drug Delivery
This study demonstrates the extension of a formerly established microfluidic hydrodynamic focusing technique for the production of small, nearly monodisperse liposomes toward the continuous-flow synthesis of PEGand PEG-folatemodified liposomes for drug delivery applications via controlled laminar flow in thermoplastic microfluidic devices. These liposomes have been used to investigate the relat...
متن کاملContinuous-Flow Production of Injectable Liposomes via a Microfluidic Approach
Injectable liposomes are characterized by a suitable size and unique lipid mixtures, which require time-consuming and nonstraightforward production processes. The complexity of the manufacturing methods may affect liposome solubility, the phase transition temperatures of the membranes, the average particle size, and the associated particle size distribution, with a possible impact on the drug e...
متن کامل